HORDB

ID: hor005193
Uniprot ID: P13189
Protein name: Glucagon
Gene name: gcg
Organism: Callorhinchus milii (Ghost shark)
Family: Glucagon family
Source: animal
Expression: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
Disease: NA
Comments: NA
Taxonomy: Callorhinchus (genus), Callorhinchidae (family), Chimaeriformes (order), Holocephali (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Function: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P13189-F1.pdb

hor005193_AF2.pdb

hor005193_ESM.pdb

Mass:	394235	Formula:	C152H225N41O49S
Absent amino acids:	CINP	Common amino acids:	S
pI:	7.53	Basic residues:	5
Polar residues:	11	Hydrophobic residues:	7
Hydrophobicity:	-91.38	Boman Index:	-8266
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	40.34
Instability Index:	7410.69	Extinction Coefficient cystines:	8480
Absorbance 280nm:	302.86

PubMed ID: 2690815
Title: Isolation and structural characterization of insulin and glucagon from the holocephalan species Callorhynchus milii (elephantfish).